Help with Focusrite setup

Good morning. I thought I was passed this problem but it's back! I have 2 interfaces hooked up to my pc. A Scarlett 2i4 and a project mix I/O. Now when I try to use the 2i4 I get a pop up that says "Problem with clock source". "Check session parameters"( I assume they mean bit depth and sample rate, etc.) These are the same settings I always use, 24 & 48. I have not changed anything on this session since I last saved and closed it. If I use the Project mix to open the same session, once I enter the proper info for that I/O the session opens and plays back. How can I get around this issue once and for all? Thanks. :rolleyes:

Help with Focusrite setup